• Pediatr. Infect. Dis. J. · Oct 2012

    Randomized Controlled Trial

    Five-year antibody persistence and safety following a booster dose of combined Haemophilus influenzae type b-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine.

    • Juan Carlos Tejedor, José Manuel Merino, Manuel Moro, Maria-Luisa Navarro, José Espín, Félix Omeñaca, José García-Sicilia, David Moreno-Pérez, Jesús Ruiz-Contreras, Fernando Centeno, Francisco Barrio, Lucia Cabanillas, Marta Muro, Carlos Esporrin, Maria Jose De Torres, Magalie Caubet, Dominique Boutriau, Jacqueline M Miller, and Narcisa Mesaros.
    • Hospital Universitario de Móstoles, Madrid, Spain. juanctejedor@telefonica.net
    • Pediatr. Infect. Dis. J. 2012 Oct 1;31(10):1074-7.

    BackgroundBooster vaccination with the combined Haemophilus influenza type b-Neisseria meningitides serogroup C-tetanus toxoid vaccine (Hib-MenC-TT) has been reported to induce different MenC antibody responses depending on the priming vaccines, with a possible impact on long-term protection. Here, the five-year persistence of immune responses induced by a booster dose of Hib-MenC-TT was evaluated in toddlers primed with either Hib-MenC-TT or MenC-TT.MethodsThis is the follow-up of a phase III, open, randomized study, in which a Hib-MenC-TT booster dose was given at 13.14 months of age to toddlers primed with either 3 doses of Hib-MenC-TT or 2 doses of MenC-TT in infancy. Children in the control group had received 3 primary doses and a booster dose of MenC-CRM197. Functional antibodies against MenC were measured by a serum bactericidal assay with rabbit complement (rSBA-MenC) and antibodies against Hib polyribosylribitol phosphate by enzyme-linked immunosorbent assay. Serious adverse events considered by the investigator to be possibly related to vaccination were to be reported throughout the study.ResultsAt 66 months postbooster, rSBA-MenC titers ≥8 were retained by 82.6% of children primed with Hib-MenC-TT, 94.1% of children primed with MenC-TT, and 60.9% of children in the control group. All children who received the Hib-MenC-TT booster dose retained anti- polyribosylribitol phosphate concentrations ≥0.15 μg/mL. No serious adverse events considered possibly related to vaccination were reported.ConclusionsThere is evidence of good antibody persistence against MenC and Hib for more than five years postbooster vaccination with Hib-MenC TT in toddlers primed with Hib-MenC-TT or MenC-TT.

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