• C Heng Vong, A Bajard, P Thiesse, E Bouffet, H Seban, and P Marec Bérard.
• Pediatric Oncology Unit, IHOP, Lyon, France.
• Pediatr Radiol. 2012 May 1;42(5):552-61.

BackgroundThe quality of MRI and CT depends largely on immobility of the patient during the procedure, which is often difficult to achieve without sedation in children below the age of 6 years.ObjectiveTo assess the efficacy and safety of intravenous chlorpromazine sedation for repeated imaging in young children treated for cancer.Materials And MethodsFrom July 2003 to January 2007, information on children younger than 6 years of age having MRI or CT was prospectively collected. Forty-five minutes before the scan, a 10-min infusion of chlorpromazine 0.5 mg/kg was administered and managed by non-anesthetic staff. Patient monitoring included continuous measurement of pulse, respiration, oxygen saturation and arterial blood pressure. Procedure-related parameters and adverse events were documented. Sedation was considered successful when the procedure was completed and at least 95% of images were usable.ResultsOne-hundred-one procedures (82 MRI, 19 CT) were evaluated in 62 children, 3-74 months old. Adequate sedation was achieved in 96% of cases, with mean induction time, 22 min; mean duration of sleep, 72 min, and mean duration of procedure, 33 min. Mean time spent in the radiology unit was 104 min. Ninety-six percent of imaging procedures were successfully completed. No cardiac, respiratory, neurological or allergic complication occurred.ConclusionIntravenous chlorpromazine is safe and effective for procedural sedation in young children with cancer undergoing MRI and CT.

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