• Zhen Ci Yan Jiu · Apr 2010

    [Effects of electroacupuncture at "Futu" (LI 18) on the immunoactivity of substance P, 5-HT 1 AR, etc. of the cervical spinal dorsal horn in rats with neck incision pain].

    • Li-na Qiao, Jun-ying Wang, Shu-ping Chen, Yong-hui Gao, Yong-sheng Yang, and Jun-ling Liu.
    • Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
    • Zhen Ci Yan Jiu. 2010 Apr 1;35(2):91-8.

    ObjectiveTo observe the effect of electroacupuncture(EA) of bilateral "Futu" (LI 18) on the immunoactivity of substance P (SP), NK-1 receptor (R), cyclooxygenase-1 (COX-1), 5-HT 1 AR and 5-HT2 AR in the cervical spinal dorsal horn of rats with neck incision pain, so as to explore its underlying mechanism in relieving incision pain.MethodsA total of 40 Wistar rats were randomly divided into control, model (incision pain), EA-Futu(LI 18), and EA-Zusanli(ST 36)-Yanglingquan (GB 34, EA-ST 36-GB 34) groups (n = 10/group). A 1.5 cm longitudinal incision was made along the middle of the neck in pentobarbital-anesthetized rats. Pain threshold (PT) was measured using radiant heat. EA (1-2 mA, 2 Hz/15 Hz) was applied to bilateral LI 18, ST 36-GB 34 for 30 min. The expression of SP, NK-1 R, COX-1, 5-HT 1 AR and 5-HT2 AR in the spinal cord (C1-C4) tissue were detected with immunohistochemistry.ResultsAfter the operation, the thermal PT was decreased obviously in markedly after treatment (P < 0.05), and no significant changes were found in PT in EA-ST 36-GB 34 group (P > 0.05). The immunoactivity of SP, NK-1 R, COX-1 in the superficial dorsal horn in model group was increased significantly and that of 5-HT 1 AR and 5-HT 2 AR significantly and mildly, separately compared with control group (P < 0.05). In comparison with model group, the immunoreactivity of SP, NK-1 R and COX-1 was decreased considerably, and that of 5-HT 1 AR and 5-HT 2 AR was upregulated remarkably in EA-LI 18 group (P < 0.05). No significant changes were found in the immunoactivity of SP, NK-1 R, COX-1, 5-HT 1 AR and 5-HT 2 AR in EA-ST 36-GB 34 group (P > 0.05).ConclusionEA-Futu (LI 18) can significantly suppress pain reaction of neck incision in the rat, which is closely associated with its effects in downregulating the expression of SP, NK-1 R, COX-1 and upregulating that of 5-HT 1 AR and 5-HT 2 AR in the spinal dorsal horn.

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