• Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · Mar 2010

    [Recovery of movement after spinal cord injury in DO11.10 transgenic mouse].

    • Hui Wang, Jun Guo, Yu Zhao, Gan-lan Bian, Fang-fang Liu, Cai-yong Yu, Rui Feng, Gong Ju, and Jian Wang.
    • Department of Neurobiology, School of Basic Medicine, Xi'an, China.
    • Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Mar 1;26(3):231-4.

    AimTo analysis the role of T lymphocytes in spinal cord regeneration by comparing the recovery of movement and the morphological changes of injury area between BALB/c and DO11.10 transgenic mice.MethodsProducing a crush injury model of spinal cord with special forceps. Analyze the changes of spinal cord injury area with H&E and GFAP, CD11b and lymphocytic immunohistochemical staining. Evaluate the recovery of movement function with Basso-Beattie-Bresnahan (BBB) locomotion testing system at 0, 7, 14 and 21 day post-injury (dpi).ResultsThere were thicker and fastened glial scar at 21 dpi in the BALB/c mice but not in DO11.10 mice. The number of macrophages/microglia infiltrated in spinal cord injury area were more in DO11.10 than that in BALB/c mice at 14 dpi. The numbers of T lymphocytes infiltrated in spinal cord injury area were less in DO11.10 than that in BALB/c mice at 21 dpi. In addition, compare to BALB/c mice, the locomotion movement recovery of DO11.10 mice were much more significant within 3 weeks after spinal cord injury by BBB scoring system.ConclusionThe infiltrated autoimmune activation T lymphocytes which specifically react to neural antigens are not beneficial to recovery of movement after spinal cord injury in mice.

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