• Crit Rev Biomed Eng · Jan 2000

    Artifact-tolerant controllers for automatic drug delivery in anesthesia.

    • C W Frei, E Bullinger, A Gentilini, A H Glattfelder, T Sieber, and A M Zbinden.
    • Automatic Control Laboratory, Swiss Federal Institute of Technology (ETH), Zurich.
    • Crit Rev Biomed Eng. 2000 Jan 1;28(1-2):187-92.

    AbstractThis article presents a method for treating measurement artifacts in model-based control systems. A nonlinear modification to the usual observer structure is introduced to prevent the measurement artifacts from winding up the controller states. It is shown how stability of the closed loop system can be analyzed and an example of a successful application in a clinical study is provided.

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