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Arzneimittel Forsch · Apr 1994
Randomized Controlled Trial Comparative Study Clinical TrialKetorolac versus diclofenac sodium in cancer pain.
- F Toscani, L Piva, O Corli, M Gallucci, R Speranza, M Tamburini, F De Conno, and V Ventafridda.
- Ospedale Civile, Milan, Italy.
- Arzneimittel Forsch. 1994 Apr 1;44(4):550-4.
AbstractIn a randomized single-blind study carried out simultaneously in five Departments for Pain Therapy and Palliative Care, the analgesic efficacy and side effects of oral ketorolac (ketorolac tromethamine, Tora-Dol, CAS 74103-07-4) and diclofenac sodium were compared in a population of 100 advanced cancer patients suffering from somatic and/or visceral pain. The treatment was carried out in agreement with the first step of the WHO pharmacological strategy in cancer pain. The administered dosage was 10 mg every 6 h for ketorolac and 50 mg every 8 h for diclofenac sodium. The study showed the efficacy of both drugs in cancer pain. A greater number of keterolac patients could pass to the second WHO step later than diclofenac patients. As to the tolerability, both drugs turned out to be similar, except for "sleepiness", which was four times more frequent (p < 0.05) in the diclofenac group.
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