• Yu-Chun Hung, Chun-Jen Huang, Chi Hang Kuok, Chien-Chuan Chen, and Yung-Wei Hsu.
• Department of Anesthesiology, Mackay Memorial Hospital, and Mackay Medicine, Nursing and Management College, Taipei, Taiwan, 10449.
• J Clin Anesth. 2005 Aug 1;17(5):353-7.

Study ObjectiveTo investigate the difference of regional cerebral oxygen saturation (rSo2) decrease in response to the decrease in mean arterial blood pressure (MAP) in young and elderly patients.DesignProspective clinical study.SettingMedical center hospital.PatientsTwenty-four American Society of Anesthesiologists physical status I and II patients, 12 of whom were young and the other 12 elderly, scheduled for elective surgery requiring general anesthesia. Patients received propofol 2 mg/kg (young patient group) and propofol 1.5 mg/kg (elderly patient group) as an induction drug.MeasurementsMAP and rSo2 were recorded continuously for 5 minutes after propofol administration.Main ResultsMAP values at the second to fifth minutes and rSo2 at the second minute after propofol administration were significantly lower than baseline in both groups (P<.05). The rSo2 decrease was minimal, and the slopes of the rSo2 decrease in response to the MAP decrease in the young and elderly groups were 0.093+/-0.012 (P<.001) and 0.112+/-0.016 (P<.001) (mean+/-SEM), respectively.ConclusionsAfter propofol induction, there was no difference between young and elderly patients in rSo2 decrease in response to the decrease in MAP.

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