-
Drug Intell Clin Pharm · Mar 1987
Case ReportsPhenytoin and phenobarbital protein binding alterations in a uremic burn patient.
- C B Pugh.
- Drug Intell Clin Pharm. 1987 Mar 1;21(3):264-7.
AbstractA case is reported in which dramatic decreases in the protein binding of phenytoin and phenobarbital were noted. A 57-year-old burn patient with a history of a seizure disorder had increased free fractions of phenytoin and phenobarbital. The patient later developed renal failure and the free fractions of both drugs were further increased. Decreases in the protein binding of phenytoin in patients with hypoalbuminemia and/or uremia have been well documented, but the effects of these conditions on phenobarbital protein binding have not been well studied. In the case described here, the presence of both hypoalbuminemia and uremia were necessary before a doubling of the free fraction of phenobarbital was noted. Although it is not a highly protein-bound drug, in some circumstances protein binding alterations of phenobarbital may be of clinical significance.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..