Drug intelligence & clinical pharmacy
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Drug Intell Clin Pharm · Mar 1987
Case ReportsPhenytoin and phenobarbital protein binding alterations in a uremic burn patient.
A case is reported in which dramatic decreases in the protein binding of phenytoin and phenobarbital were noted. A 57-year-old burn patient with a history of a seizure disorder had increased free fractions of phenytoin and phenobarbital. ⋯ In the case described here, the presence of both hypoalbuminemia and uremia were necessary before a doubling of the free fraction of phenobarbital was noted. Although it is not a highly protein-bound drug, in some circumstances protein binding alterations of phenobarbital may be of clinical significance.