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Clin Neurol Neurosurg · Jul 2006
Freezing of gait after bilateral subthalamic nucleus stimulation for Parkinson's disease.
- Justin T Davis, Kelly E Lyons, and Rajesh Pahwa.
- University of Kansas Medical Center, Department of Neurology, 3599 Rainbow Blvd., Kansas City, KS 66160, USA.
- Clin Neurol Neurosurg. 2006 Jul 1;108(5):461-4.
ObjectiveTo determine the long-term effect of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on freezing of gait in Parkinson's disease patients.Patients And MethodsSixty-seven patients were followed 12 months after bilateral STN DBS and 32 patients were followed 24 months post-surgery. Patients were evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS) with medications on and off at baseline and again in both conditions with stimulation on at follow-up. Specific attention was paid to the freezing item of the ADL section.ResultsFreezing scores in the medication off state improved significantly with stimulation at 1 and 2 years. In the medication on state there were no significant improvements in freezing.ConclusionOff period freezing of gait is significantly improved with STN DBS up to 24 months; however, on period freezing is not affected by STN DBS.
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