• Kulsoom Farhat, Javeid Iqbal, Akbar Waheed, Qaisar Mansoor, Muhammad Ismail, and Anwar Kamal Pasha.
• Department of Pharmacology and Therapeutics, Army Medical College, Rawalpindi.
• J Coll Physicians Surg Pak. 2015 Jul 1; 25 (7): 486-90.

ObjectiveTo determine the association of ABCB1 polymorphism G2677T with anti-emetic efficacy in patients treated with ondansetron for preventing postoperative nausea and vomiting.Study DesignA clinical trial.Place And Duration Of StudyCombined Military Hospital, Rawalpindi and Institute of Biomedical and Genetic Engineering, Islamabad, from 2012 to 2013.MethodologyFour mg ondansetron was administered intravenously 30 minutes before the end of surgery. A total of 246 patients with the complaints of nausea and vomiting and 244 patients without nausea and vomiting were analyzed for G2677T polymorphism using PCR-RFLP method. Results were described as frequency percentages and chi-square test with significance at p < 0.05.ResultsThe patients with TT genotype had significantly lower incidence of postoperative nausea and vomiting during the first 2 hours (p < 0.001) and between 2 - 24 hours after surgery as compared to other genotypes (p < 0.001). The patients with GG genotypes had significantly higher incidence of this complaint (p=0.014).ConclusionPolymorphism of ABCB1 has an association with responsiveness for ondansetron. There is a role for genetics in the management of PONV.

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