• Koichi Omori, Yasuhiro Tada, Teruhisa Suzuki, Yukio Nomoto, Takashi Matsuzuka, Ken Kobayashi, Tatsuo Nakamura, Shinichi Kanemaru, Masaru Yamashita, and Ryo Asato.
• Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Japan.
• Ann Oto Rhinol Laryn. 2008 Sep 1;117(9):673-8.

ObjectivesThe objective of the present study was to demonstrate the efficacy of the clinical application of in situ tissue engineering using a scaffolding technique for laryngeal and tracheal tissue.MethodsWe have developed a tissue scaffold made from a Marlex mesh tube covered by collagen sponge. Based on successful animal experimental studies, in situ tissue engineering with a scaffold implant was applied to repair the larynx and trachea in 4 patients.ResultsIn 1 patient with subglottic stenosis, the thyroid cartilage, cricoid cartilage, and cervical trachea with scarring and granulation were resected and reconstructed by use of the scaffold. In 3 patients with thyroid cancer, the trachea and cricoid cartilage with tumor invasion were resected and the scaffold was implanted into the defect. Postoperative endoscopy during the observation period of 8 to 34 months showed a well-epithelialized airway lumen without any obstruction.ConclusionsOur current technique of in situ tissue engineering using a scaffold shows great potential for use in the regeneration of airway defects.

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