Ann Oto Rhinol Laryn
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Ann Oto Rhinol Laryn · Sep 2008
Review Case ReportsLemierre's syndrome: what are the roles for anticoagulation and long-term antibiotic therapy?
We wanted to describe what Lemierre's syndrome is and what risk factors may be involved, and to understand the roles, if any, of antibiotics and anticoagulants in the treatment of this syndrome. ⋯ Because Lemierre's syndrome is so rare, it is difficult to ascertain absolutely the need for either anticoagulation or long-term antibiotic therapy. At this time, the risks and benefits of providing either therapy must be weighed against the potential complications of incompletely treating septic thrombosis.
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Ann Oto Rhinol Laryn · Sep 2008
Case ReportsClinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea.
The objective of the present study was to demonstrate the efficacy of the clinical application of in situ tissue engineering using a scaffolding technique for laryngeal and tracheal tissue. ⋯ Our current technique of in situ tissue engineering using a scaffold shows great potential for use in the regeneration of airway defects.
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Sedation for laryngeal framework surgery has lacked easy modulation between appropriate pain control, airway protection, and the alertness appropriate for vocal testing. Our objective was to determine whether dexmedetomidine hydrochloride could safely and effectively be used as the sole intravenous anesthetic agent in conjunction with local anesthesia for laryngeal framework procedures. ⋯ We believe that dexmedetomidine provides excellent sedative and operative conditions for awake laryngeal framework procedures. Coupled with local anesthesia, dexmedetomidine produced virtually no undesirable hemodynamic or respiratory effects, while allowing for adequate sedation the majority of the time. The operative conditions were markedly improved over those of previous standard monitored anesthesia regimens.