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Pediatr. Infect. Dis. J. · May 2012
Safety and pharmacokinetics of oseltamivir for prophylaxis of neonates exposed to influenza H1N1.
- Helena C Maltezou, Nikolaos Drakoulis, Tania Siahanidou, Vangelis Karalis, Eirini Zervaki, Yannis Dotsikas, Yannis L Loukas, and Maria Theodoridou.
- Department for Interventions in Health-Care Facilities, Hellenic Centre for Diseases Control and Prevention, Athens, Greece. helen-maltezou@ath.forthnet.gr
- Pediatr. Infect. Dis. J. 2012 May 1; 31 (5): 527-9.
AbstractOseltamivir was administered at 1.0 mg/kg b.i.d. to 13 neonates exposed to influenza H1N1. No influenza, neurologic, or laboratory adverse effects occurred. The mean Cmax values for oseltamivir and oseltamivir carboxylate were found to be lower than those reported for children 1 to 5 years old, whereas Tmax values were similar to children 1 to 5 years old. Age and gender were found to significantly affect oseltamivir clearance.
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