• Nan Fang Yi Ke Da Xue Xue Bao · Oct 2009

    Meta Analysis

    [Effect of levosimendan on B-type natriuretic peptide levels in patients with advanced heart failure: a meta-analysis].

    • Zhong-dong Xu, Wei-xiong He, Yi-fan Zhao, Shu-xuan Xia, Bo He, Tao Yang, De-xiong Cao, Shu-ling Peng, Jue Li, and Ming-hui Cao.
    • Department of Anesthesiology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China. xuzhongdong88@163.com
    • Nan Fang Yi Ke Da Xue Xue Bao. 2009 Oct 1; 29 (10): 2027-9.

    ObjectiveTo conduct a meta-analysis of the effect of levosimendan on B-type natriuretic peptide (BNP) levels and evaluate the therapeutic effect of levosimendan on advanced heart failure.MethodsA meta-analysis was performed on the selected data to analyze the effect of levosimendan on BNP levels.ResultsLevosimendan decreased BNP by a mean of 337.66 [95%CI (-296.30, -379.02)] pg/ml 24 h after the administration, and by 259.92 [95%CI (-195.76, -324.08)] pg/ml at 48 h, and by 123.09 [95%CI(-53.32,-195.86)] pg/ml at 1 week. Levosimendan resulted in improvements of the cardiac function by about 29%, 22%, and 10% at 24 h, 48 h and 1 week after the administration.ConclusionLevosimendan produces favorable effects on the cardiac functions and BNP levels.

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