• Arch Neurol Chicago · Dec 2004

    Comparative Study

    Musculoskeletal pain in patients with myotonic dystrophy type 2.

    • Annette George, Christiane Schneider-Gold, Sandra Zier, Karlheinz Reiners, and Claudia Sommer.
    • Department of Neurology, University of Würzburg, Josef-Schneider-Strasse 11, 97080 Würzburg, Germany.
    • Arch Neurol Chicago. 2004 Dec 1; 61 (12): 1938-42.

    BackgroundMyotonic dystrophy type 2/proximal myotonic myopathy (DM2/PROMM) is an autosomal dominant multisystem disorder. Musculoskeletal pain is one of its frequent symptoms but also occurs in other chronic noninflammatory muscle disorders (OMD).ObjectivesTo characterize the phenotype of DM2/PROMM-associated musculoskeletal pain and to test whether it shows features distinct from OMD.SettingOutpatient clinic for patients with neuromuscular disorders, university hospital.PatientsTwenty-four patients with DM2/PROMM (12 women and 12 men; median age, 57 years) and 24 age- and sex-matched patients with OMD consecutively recruited during a 3-year period were examined for musculoskeletal pain.MethodsStandardized pain assessment; McGill Pain Questionnaire; depression score; and quantification of pain thresholds to blunt pressure on limb muscles with analgometer.ResultsUnlike patients with OMD who have musculoskeletal pain, patients with DM2/PROMM distinguished a wide spectrum of coexisting pain types. The major pain type in patients with DM2/PROMM was exercise-related, temperature-modulated, and palpation-induced, whereas, cramps were rare. In 8 of the patients with DM2/PROMM and in 3 of the patients with OMD, musculoskeletal pain was the most disabling symptom.ConclusionBesides many similarities, DM2/PROMM-associated musculoskeletal pain shows features distinct from OMD.

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