• T Vutyavanich, S Wongtra-ngan, and R Ruangsri.
• Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand.
• Am. J. Obstet. Gynecol. 1995 Sep 1; 173 (3 Pt 1): 881-4.

ObjectiveOur purpose was to determine the effectiveness of pyridoxine for nausea and vomiting of pregnancy.Study DesignDuring an 11-month period 342 women who first attended Chiang Mai University Hospital antenatal clinic at < or = 17 weeks' gestation were randomized to received either oral pyridoxine hydrochloride, 30 mg per day, or placebo in a double-blind fashion. Patients graded the severity of their nausea by a visual analog scale and recorded the number of vomiting episodes over the previous 24 hours before treatment and again during 5 consecutive days on treatment.ResultsThere was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0.0008). There was also a greater reduction in the mean number of vomiting episodes, but the differences did not reach statistical significance (p = 0.0552).ConclusionPyridoxine is effective in relieving the severity of nausea in early pregnancy.

16 keywords...

hide…