American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Sep 1995
Randomized Controlled Trial Clinical TrialThe effect of topical 20% benzocaine on pain during loop electrosurgical excision of the cervix.
Our purpose was to evaluate the effect of cervical application of 20% benzocaine on the pain associated with subsequent cervical injection of local anesthetic and tissue excision during the loop electrosurgical excision procedure of the cervix. ⋯ Preoperative cervical application of 20% benzocaine does not appear to reduce the pain associated with either subsequent local anesthetic injection or tissue excision during the loop electrosurgical excision procedure of the cervix.
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Am. J. Obstet. Gynecol. · Sep 1995
Randomized Controlled Trial Clinical TrialPyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial.
Our purpose was to determine the effectiveness of pyridoxine for nausea and vomiting of pregnancy. ⋯ Pyridoxine is effective in relieving the severity of nausea in early pregnancy.
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Am. J. Obstet. Gynecol. · Sep 1995
Onapristone (ZK 98.299): a potential antiprogestin for endometrial contraception.
The effects of the antiprogestin onapristone (ZK 98.299) on fertility; menstrual cycle length; duration of menses; serum estradiol, progesterone, and cortisol concentrations; and endometrial morphologic features were studied in adult bonnet monkeys. ⋯ This study demonstrates that low-dose onapristone treatment throughout the menstrual cycle prevents pregnancy without disturbing the menstrual cycle and ovulation in the majority of cycles. However, anovulation and luteal insufficiency occurred in some animals during prolonged treatment. The contraceptive effect in the ovulatory cycles seems primarily related to the retardation of endometrial development resulting in the inhibition of endometrial receptivity. It appears likely that a dose or treatment regimen of onapristone that will inhibit endometrial receptivity and prevent implantation without affecting the menstrual cycle even on prolonged treatment could be identified.