• J Clin Anesth · Feb 2015

    Review

    Glutathione S-transferase as a toxicity indicator in general anesthesia: genetics and biochemical function.

    • Adam Mikstacki, Oliwia Zakerska-Banaszak, Marzena Skrzypczak-Zielinska, Barbara Tamowicz, Marlena Szalata, and Ryszard Slomski.
    • Department of Anesthesiology and Intensive Therapy, Regional Hospital, Poznan, Poland.
    • J Clin Anesth. 2015 Feb 1;27(1):73-9.

    AbstractGeneral anesthesia may lead in patients to unexpected and adverse reactions including toxicity. Glutathione S-transferases (GSTs) are enzymes responsible for the detoxification process of anesthetic agents. Plasma and urine GST measurements are used in multiple studies as a hepatocellular integrity or renal injury indicator. The importance of GST enzyme measurements in monitoring the hepatotoxic and nephrotoxic effect in anesthetized patients is presented. The biochemical function and specific properties of GST render it a prognostic biomarker. This review demonstrates that GST can be valuable and promising toxicity indicator in patients undergoing general anesthesia.Copyright © 2014 Elsevier Inc. All rights reserved.

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