• J Clin Anesth · Mar 1996

    Case Reports

    High-dose oral morphine in cancer pain management: a report of twelve cases.

    • L Radbruch, S Grond, D J Zech, and A Bischoff.
    • Department of Anaesthesiology, University of Cologne, Germany.
    • J Clin Anesth. 1996 Mar 1; 8 (2): 144-50.

    AbstractWe present 12 case reports from patients treated with more than 600 mg of morphine per day. We found no "opioid-nonresponsive pain" under treatment with a combination of morphine and nonopioids, supplemented with coanalgesics where appropriate. Side effects of morphine therapy were controlled with adjuvant drugs. Serious adverse effects were not observed. Episodes of break-through pain, dysphagia, and dyspnea caused by far advanced cancer disease were seen frequently.

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