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- L Radbruch, S Grond, D J Zech, and A Bischoff.
- Department of Anaesthesiology, University of Cologne, Germany.
- J Clin Anesth. 1996 Mar 1; 8 (2): 144-50.
AbstractWe present 12 case reports from patients treated with more than 600 mg of morphine per day. We found no "opioid-nonresponsive pain" under treatment with a combination of morphine and nonopioids, supplemented with coanalgesics where appropriate. Side effects of morphine therapy were controlled with adjuvant drugs. Serious adverse effects were not observed. Episodes of break-through pain, dysphagia, and dyspnea caused by far advanced cancer disease were seen frequently.
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