• D Y Bisschop, J P Alardo, B Razgallah, B Y Just, M L Germain, H G Millart, and T C Trenque.
• Centre Régional de Pharmacovigilance, Hôpital Maison Blanche, Reims, France.
• Ann Pharmacother. 2001 Mar 1; 35 (3): 311-3.

ObjectiveTo report development of a seizure after administration of ropivacaine.Case SummaryA 26-year-old woman was scheduled for a cesarean section because of a stagnation of the uterine neck dilatation after 4.5 hours. After peridural administration of 279 mg of ropivacaine (total dose) over five hours, she presented with oculogyric movements and slurred speech that preceded convulsions of the face and of the upper limbs.DiscussionConvulsions are well-known complications of local anesthetics. Ropivacaine, a relatively new agent, is considered safer for the central nervous system. Currently, there are only four published reports that implicate ropivacaine as being associated with convulsions. The likelihood that ropivacaine caused the seizure in our patient was possible based on the Naranjo probability scale.ConclusionsClinicians should be aware of the possibility of seizures as an adverse effect of ropivacaine.

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