• L Bennasr, S Ben Marzouk, Z Ajili, A Riahi, M A Jarraya, S Massoudi, H Jabri, and H Maghrebi.
• Service d'anesthésie-réanimation, faculté de médecine de Tunis, centre de maternité et de néonatalogie de Tunis, université de Tunis El Manar, rue Jabel-Lakhdar, La Rabta, 1007 Tunis, Tunisie.
• Ann Fr Anesth Reanim. 2014 Dec 1;33(12):643-7.

ObjectiveThe aim of this study was to compare the efficacy of HES 130/0.4 coloading compared to normal saline solution for prevention of hypotension during spinal anesthesia for elective caesarean section.Study DesignProspective, randomized.Patients And MethodsOne hundred and twenty ASA I and II patients scheduled for elective caesarean section were recruited. Patients were randomized to receive either 500mL of HES 130/0.4 (Voluven(®)) coloading (GroupV) or 500mL of normal saline solution coloading (GroupC). Spinal anesthesia technique and ephedrine administration were standardized in both groups. The primary endpoint was the incidence of maternal hypotension during spinal anesthesia for elective caesarean section.ResultsHypotension occurred in 43 patients in group C and 24 patients in group V (p=0.001). Ephedrine consumption was significantly lower in group V (P=0.005). Nausea, vomiting and headache incidence was higher in group C (p=0.006). Apgar scores and umbilical blood gazes were comparable between groups.ConclusionHES 130/0.4 coload was more effective than normal saline solution to prevent hypotension following spinal anesthesia for elective cesarean section. HES 130/0.4 coload reduced the incidence, the duration of longest hypotension, the need for ephedrine and the adverse maternal effects.Copyright © 2014 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved.

33 keywords...

hide…