-
Pediatric blood & cancer · Aug 2012
ReviewMicronutrients and sickle cell disease, effects on growth, infection and vaso-occlusive crisis: a systematic review.
- Louise H Dekker, Karin Fijnvandraat, Bernard J Brabin, and Michael Boele van Hensbroek.
- Department of Public Health, Academic Medical Center, Amsterdam, The Netherlands. l.h.dekker@amc.uva.nl
- Pediatr Blood Cancer. 2012 Aug 1; 59 (2): 211-5.
AbstractPatients with Sickle cell disease (SCD) exhibit signs of poor growth, increased susceptibility to infection and recurrent episodes of painful vaso-occlusive crises. Micronutrient deficiencies may increase susceptibility to these outcomes. We conducted a systematic review to assess the strength of evidence for improved outcomes related to micronutrient interventions. Six randomized-controlled trials of moderate quality met the inclusion criteria. Zinc supplementation was associated with improved growth and decreased incidence of infection and is a promising intervention in the management of SCD patients. Omega-3 fatty acid supplementation was associated with limited reduction in vaso occlusive crises. This review identifies key knowledge gaps, which are important research priorities for nutritional interventions.Copyright © 2012 Wiley Periodicals, Inc.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..