• A Clavé, F Fazilleau, D Dumser, and J Lacroix.
• Western Britany University, Faculty of Medicine, 3, rue des Archives, 29285 Brest, France. arnaud.clave@chu-brest.fr
• Orthop Traumatol Sur. 2012 Sep 1; 98 (5): 484-90.

IntroductionPerioperative blood loss is a frequent cause of complications in total hip replacement (THR). The present prospective study assessed the efficacy of tranexamic acid (Exacyl(®)) in reducing blood loss in primary THR associated to rivaroxaban (Xarelto(®)) thromboprophylaxis.HypothesisTranexamic acid associated to rivaroxaban reduces blood loss.Material And MethodA prospective case-control study included 70 primary cementless THRs performed by a single surgeon on a standardized technique, between September 2009 and September 2010. Thirty-seven patients received perioperative tranexamic acid; all patients received rivaroxaban thromboprophylaxis.ResultsThere was no significant difference between the two groups in terms of peroperative blood-loss volume or rates of thromboembolic or ischemic events or hematoma. Postoperative blood loss, D0-5 differential hemoglobinemia and real blood loss (in mL 100% hematocrit) were significantly lower in the tranexamic acid group. No transfusions were required in the tranexamic acid group, versus four in the control group.DiscussionTranexamic acid associated to direct anti-Xa (antithrombin-independent) oral anticoagulants was effective in reducing postoperative blood loss, improving hemoglobinemia at 5 days and reducing transfusion rates. The results also confirmed the efficacy of and tolerance for rivaroxaban thromboprophylaxis in primary THR, with no clinical thrombotic events induced by the association of tranexamic acid with rivaroxaban.ConclusionsTranexamic acid is a simple means of reducing postoperative blood loss in THR, without increased risk of thromboembolism when associated to rivaroxaban thromboprophylaxis.Level Of EvidenceLevel III prospective case-control study.Copyright © 2012 Elsevier Masson SAS. All rights reserved.

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