• G E Larijani, I Gratz, and M Afshar.
• Department of Anesthesiology, Medical College of Pennsylvania, Philadelphia 19129.
• Ann Pharmacother. 1994 Feb 1; 28 (2): 179-81.

ObjectiveTo evaluate the presence and the relationship between postoperative nystagmus and nausea.DesignOpen-label study.SettingUniversity hospital.PatientsSixty-six patients recovering from general anesthesia following elective ambulatory surgeries.InterventionsPatients were tested postoperatively for nystagmus using an electronystagmography, and were monitored for nausea and vomiting for the first postoperative day.Main Outcome MeasuresA comparison of the incidence of nausea was made among patients with and without postoperative nystagmus.ResultsTwenty-four patients (36 percent) experienced postoperative nausea and 28 patients (42 percent) had nystagmus. There were no significant differences in age, weight, height, dosage of fentanyl, or postoperative use of narcotics between those who experienced postoperative nausea or had nystagmus than those who did not. A significantly greater percentage of female patients compared with male patients had nausea during the first postoperative day. Sixty percent of patients with nystagmus experienced nausea in the hospital compared with 18 percent of the patients without nystagmus (p < 0.01, 95 percent confidence interval [CI] of the difference = 11.3 to 61.3 percent). Twenty-two patients (78 percent) with nystagmus experienced nausea during the first postoperative day compared with 14 patients (36 percent) with no nystagmus (p < 0.01, 95 percent CI of the difference = 20.1 to 63.3 percent). Eighty-three percent of the nauseated patients experienced vomiting during the first postoperative day.ConclusionsThe presence of nystagmus in the early part of recovery from general anesthesia is associated with a higher incidence of nausea and vomiting during the first postoperative day.

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