• M Nakayama, N Kanaya, H Tsuchida, and A Namiki.
• Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan.
• J Clin Anesth. 1999 Feb 1; 11 (1): 8-10.

Study ObjectiveTo compare the effects of propofol and thiamylal on the hyperdynamic circulatory response caused by a rapid increase in isoflurane concentration.DesignProspective, randomized, double-blind study.SettingOperating rooms of a university hospital.Patients30 ASA physical status I adult patients scheduled for elective surgery with general anesthesia.InterventionsPatients were anesthetized with either propofol 2 mg/kg (propofol group, n = 15) or thiamylal 4 mg/kg (thiamylal group, n = 15). Two minutes after anesthesia induction, the inspired isoflurane concentration was rapidly increased from 0.5% to 5% and maintained for 5 minutes.Measurements And Main ResultsMean arterial pressure significantly increased after the increase in isoflurane concentration in the thiamylal group, but it did not change in the propofol group. The isoflurane-induced increase in rate-pressure product was significantly greater in the thiamylal group than in the propofol group.ConclusionPropofol induction of anesthesia more effectively attenuates the circulatory responses to a sudden increase in isoflurane concentration than does thiamylal.

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