Depth of anesthesia can be indirectly measured by Bispectral Index (BIS), therefore it is possible to administer propofol in a closed loop to maintain the optimal level of anesthesia while minimizing the dose to improve the postanesthesia recovery. High-Order Sliding-Mode control can be used to individualize drug dosing. In this study, the controller is tested with four in silico patients.
Ana Gallardo Hernández, Jonathan Eslava Escobar, Ron Leder, Ana Luisa Hernández Pérez, Leonid Fridman, Jorge Dávila, Cristina Revilla Monsalve, and Sergio Islas Andrade.
Conf Proc IEEE Eng Med Biol Soc. 2013 Jan 1; 2013: 201-4.
AbstractDepth of anesthesia can be indirectly measured by Bispectral Index (BIS), therefore it is possible to administer propofol in a closed loop to maintain the optimal level of anesthesia while minimizing the dose to improve the postanesthesia recovery. High-Order Sliding-Mode control can be used to individualize drug dosing. In this study, the controller is tested with four in silico patients.