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Case Reports
Oseltamivir-resistant pandemic (H1N1) 2009 influenza in a severely ill patient: the first Australian case.
- David J Speers, Simon H Williams, Mary Pinder, Harry R Moody, Aeron C Hurt, and David W Smith.
- Division of Microbiology and Infectious Diseases, PathWest Laboratory Medicine WA, Perth, WA. david.speers@health.wa.gov.au
- Med. J. Aust. 2010 Feb 1; 192 (3): 166-8.
AbstractAfter a 10-day course of oral oseltamivir for pandemic (H1N1) 2009 influenza infection, a renal transplant recipient developed rapid-onset severe primary viral pneumonia due to oseltamivir-resistant virus. Respiratory failure progressed despite high-dose oral oseltamivir, nebulised zanamivir and cessation of immunosuppressive medications, but his condition improved with intravenous zanamivir. He subsequently died of non-respiratory complications. This is the first case of oseltamivir-resistant pandemic (H1N1) 2009 in Australia and the first report of resistance in a solid organ transplant recipient.
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