• Pain · Jan 1987

    Randomized Controlled Trial Clinical Trial

    Intravenous lidocaine infusion--a new treatment of chronic painful diabetic neuropathy?

    • Jens Kastrup, Palle Petersen, Anders Dejgård, Helle R Angelo, and Jannik Hilsted.
    • Department of Clinical Physiology and Nuclear Medicine, CopenhagenDenmark Clinical Chemistry, Bispebjerg Hospital, CopenhagenDenmark Department of Neurology N, Rigshospitalet, CopenhagenDenmark Hvidøre Hospital Klampenborg, CopenhagenDenmark Department of Medicine F, Glostrup Hospital, CopenhagenDenmark.
    • Pain. 1987 Jan 1; 28 (1): 697569-75.

    AbstractIn a randomized double-blind, cross-over study the effect of intravenous lidocaine (5 mg/kg body weight) on the symptoms and signs of painful diabetic neuropathy of more than 6 months duration has been evaluated. Using a clinical symptom scale, there was significant beneficial effect 1 and 8 days after lidocaine infusion compared to after saline infusion (P less than 0.05 and P less than 0.02, respectively). The duration of the individual effect ranged from 3 to 21 days. Lidocaine infusion had no effect on the objective measurements of neuropathy. Intravenous lidocaine infusion seems to be a new alternative treatment of chronic painful diabetic neuropathy.

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