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Randomized Controlled Trial Clinical Trial
Intravenous lidocaine infusion--a new treatment of chronic painful diabetic neuropathy?
- J Kastrup, P Petersen, A Dejgård, H R Angelo, and J Hilsted.
- Pain. 1987 Jan 1; 28 (1): 69-75.
AbstractIn a randomized double-blind, cross-over study the effect of intravenous lidocaine (5 mg/kg body weight) on the symptoms and signs of painful diabetic neuropathy of more than 6 months duration has been evaluated. Using a clinical symptom scale, there was significant beneficial effect 1 and 8 days after lidocaine infusion compared to after saline infusion (P less than 0.05 and P less than 0.02, respectively). The duration of the individual effect ranged from 3 to 21 days. Lidocaine infusion had no effect on the objective measurements of neuropathy. Intravenous lidocaine infusion seems to be a new alternative treatment of chronic painful diabetic neuropathy.
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