• Antimicrob. Agents Chemother. · Oct 2010

    Colistin dosing and nephrotoxicity in a large community teaching hospital.

    • C Andrew Deryke, Amanda J Crawford, Nizam Uddin, and Mark R Wallace.
    • Department of Pharmacy, Orlando Health, Orlando, Florida, USA. andrew.deryke@orlandohealth.com
    • Antimicrob. Agents Chemother. 2010 Oct 1; 54 (10): 4503-5.

    AbstractThirty adult patients who received intravenous colistin (5.1 ± 2.4 mg/kg/day) were reviewed to evaluate dosing with respect to nephrotoxicity, which occurred in 10 (33%) patients within the first 5 days of treatment. Excessive colistin dosing was frequent (47%), often (71%) resulted from the use of actual body weight in obese patients, and was associated with higher rates of nephrotoxicity (80% versus 30%, P = 0.019).

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