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- Leslie L Kerst and Vincent F Mauro.
- The Medical Center of Aurora, 1501 S. Potomac Street, Aurora, CO 80012-5411, USA. leslie.kerst@HealthONEcares.com
- Ann Pharmacother. 2004 Jun 1; 38 (6): 1060-4.
ObjectiveTo review the evidence for statin secondary prevention of coronary artery disease in patients with near-optimal or optimal low-density lipoprotein cholesterol (LDL-C).Data SourcesA MEDLINE search (1966-October 2003) was conducted using the search terms HMG-CoA reductase inhibitor, statins, coronary disease, post-myocardial infarction, and average cholesterol.Data SynthesisSecondary prevention trials enrolling subjects with near-optimal (<130 mg/dL) or optimal (<100 mg/dL) baseline LDL-C were included. Early statin secondary prevention studies suggested attenuated benefit, but more recent trials challenge this finding.ConclusionsStatin secondary prevention of coronary artery disease in patients near goal LDL-C is controversial, but recent trial results show promise.
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