• Lung Cancer · Apr 2008

    Case Reports

    Heterogeneity of epidermal growth factor receptor mutations within a mixed adenocarcinoma lung nodule.

    • Hirofumi Nakano, Hiroshi Soda, Mineyo Takasu, Nanae Tomonaga, Hiroyuki Yamaguchi, Katsumi Nakatomi, Satoru Fujino, Tomayoshi Hayashi, Yoichi Nakamura, Kazuhiro Tsukamoto, and Shigeru Kohno.
    • Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan.
    • Lung Cancer. 2008 Apr 1; 60 (1): 136-40.

    AbstractIt has been proposed that stepwise progression occurs from atypical adenomatous hyperplasia (AAH) through bronchioloalveolar carcinoma (BAC) to invasive lung adenocarcinoma. However, the underlying molecular mechanisms have not been identified. We report a patient with a mixed adenocarcinoma of the lung that had different EGFR mutations in the papillary subtype, the acinar subtype, and the surrounding AAH and BAC areas. EGFR mutations may accumulate during tumor progression and lead to heterogeneity of EGFR mutations within the tumor.

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