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- Muhammad Mamdani, Andrew Ching, Brian Golden, Magda Melo, and Ulrich Menzefricke.
- Applied Health Research Centre, Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.
- Ann Pharmacother. 2008 May 1; 42 (5): 704-7.
AbstractAlthough there appears to be widespread support of evidence-based medicine as a basis for rational prescribing, the challenges to it are significant and often justified. A multitude of factors other than evidence drive clinical decision-making, including patient preferences and social circumstances, presence of disease-drug and drug-drug interactions, clinical experience, competing demands from more pressing clinical conditions, marketing and promotional activity, and system-level drug policies.
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