• Medical hypotheses · Jul 2009

    Atropine may prevent the development of neurogenic pulmonary edema.

    • Jirí Sedý, Josef Zicha, Jaroslav Kunes, and Eva Syková.
    • Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic. jirisedy@hotmail.com
    • Med. Hypotheses. 2009 Jul 1; 73 (1): 42-4.

    AbstractNeurogenic pulmonary edema is an acute life-threatening complication of central nervous system injury. We introduce a hypothesis that early i.v. administration of high-dose atropine can prevent neurogenic pulmonary edema development on the basis of the prevention of baroreflex-induced bradycardia, which was recognized as a major factor in neurogenic pulmonary edema formation. To validate this hypothesis, a clinical trial in patients suffering from subarachnoid haemorrhage should be performed, with atropine administered i.v. immediately after the maintenance of the living functions, intubation and ability to monitor patient.

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