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- Jirí Sedý, Josef Zicha, Jaroslav Kunes, and Eva Syková.
- Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic. jirisedy@hotmail.com
- Med. Hypotheses. 2009 Jul 1; 73 (1): 42-4.
AbstractNeurogenic pulmonary edema is an acute life-threatening complication of central nervous system injury. We introduce a hypothesis that early i.v. administration of high-dose atropine can prevent neurogenic pulmonary edema development on the basis of the prevention of baroreflex-induced bradycardia, which was recognized as a major factor in neurogenic pulmonary edema formation. To validate this hypothesis, a clinical trial in patients suffering from subarachnoid haemorrhage should be performed, with atropine administered i.v. immediately after the maintenance of the living functions, intubation and ability to monitor patient.
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