-
Comparative Study
Immunomodulatory effects of orally administered cannabinoids in multiple sclerosis.
- J Killestein, E L J Hoogervorst, M Reif, B Blauw, M Smits, B M J Uitdehaag, L Nagelkerken, and C H Polman.
- Department of Neurology, VU Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. J.Killestein@vumc.nl
- J. Neuroimmunol. 2003 Apr 1; 137 (1-2): 140-3.
AbstractCannabinoids can modulate the function of immune cells. We here present the first human in vivo study measuring immune function in 16 MS patients treated with oral cannabinoids. A modest increase of TNF-alpha in LPS-stimulated whole blood was found during cannabis plant-extract treatment (p=0.037), with no change in other cytokines. In the subgroup of patients with high adverse event scores, we found an increase in plasma IL-12p40 (p=0.002). The results suggest pro-inflammatory disease-modifying potential of cannabinoids in MS.
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