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Annals of neurology · Sep 2014
Case ReportsTargeted treatment of migrating partial seizures of infancy with quinidine.
- David Bearden, Alanna Strong, Jessica Ehnot, Marissa DiGiovine, Dennis Dlugos, and Ethan M Goldberg.
- Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA.
- Ann. Neurol. 2014 Sep 1; 76 (3): 457-61.
AbstractMigrating partial seizures of infancy is an early onset epileptic encephalopathy syndrome that is typically resistant to treatment. The most common cause is a gain of function mutation in the potassium channel KCNT1. The antiarrhythmic drug quinidine is a partial antagonist of KCNT1 and hence may be a candidate drug for treatment of this condition. We report the case of a child with migrating partial seizures of infancy secondary to an activating mutation in KCNT1 treated with quinidine. Treatment with quinidine was correlated with a marked reduction in seizure frequency and improved psychomotor development.© 2014 American Neurological Association.
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