• Annals of neurology · Sep 2014

    Case Reports

    Targeted treatment of migrating partial seizures of infancy with quinidine.

    • David Bearden, Alanna Strong, Jessica Ehnot, Marissa DiGiovine, Dennis Dlugos, and Ethan M Goldberg.
    • Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA.
    • Ann. Neurol. 2014 Sep 1; 76 (3): 457-61.

    AbstractMigrating partial seizures of infancy is an early onset epileptic encephalopathy syndrome that is typically resistant to treatment. The most common cause is a gain of function mutation in the potassium channel KCNT1. The antiarrhythmic drug quinidine is a partial antagonist of KCNT1 and hence may be a candidate drug for treatment of this condition. We report the case of a child with migrating partial seizures of infancy secondary to an activating mutation in KCNT1 treated with quinidine. Treatment with quinidine was correlated with a marked reduction in seizure frequency and improved psychomotor development.© 2014 American Neurological Association.

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