• Zhonghua Jie He He Hu Xi Za Zhi · Nov 2000

    [Effects of permissive hypercapnia on pulmonary mechanics and hemodynamics in sheep with acute lung injury].

    • Y Tan, H Qiu, and F Guo.
    • Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, China.
    • Zhonghua Jie He He Hu Xi Za Zhi. 2000 Nov 1; 23 (11): 683-5.

    ObjectiveTo study the effects of permissive hypercapnia (PHC) on pulmonary mechanics and hemodynamics in sheep with acute lung injury (ALI).MethodsIn 18 sheep with LPS induced ALI, gas exchange, pulmonary mechanics and hemodynamics were observed at different tidal volumes (VT).ResultsWhen VT was decreased from 16 ml/kg to 4-7 ml/kg, PHC was induced. Arterial pressure of carbon dioxide increased markedly, arterial oxygen pressure, oxygen saturation and mixed venous oxygen saturation decreased (P < 0.05). Airway pressure decreased significantly (P < 0.05), but the airway resistance increased. Systemic and pulmonary vascular resistance index, right and left ventricular stroke work index increased in PHC, but heart rate decreased (P < 0.05). Compared with VT 16 ml/kg, cardiac index decreased markedly in PHC. In static pressure-volume curve, the pressure of upper inflection point was (21.8 +/- 3.2) cm H2O, volume was (10.7 +/- 1.3) ml/kg.ConclusionsAlveolar overdistention may be prevented only when airway plateau pressure is less than 20-25 cm H2O, but cardiac index is decreased.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…