• Gustavo José Von Glehn dos Santos, Eduardo Hatschbach, Ewaldo de Mattos Júnior, and Flávio Massone.
• Faculty of Veterinary Medicine and Zootechny, Laboratory of Veterinary Anesthesiology, Julio de Mesquita Filho University, Botucatu, São Paulo, Brazil.
• Acta Cir Bras. 2006 Sep 1; 21 (5): 304-9.

PurposeTo evaluate the parameters of dogs anesthetized by different dissociative drugs protocols through continuous intravenous infusion.MethodsThirty healthy dogs of both sexes were assigned randomly to three groups (G1, G2, and G3). G1 was administered with methotrimeprazine as a pre-anesthetic medication, intravenously midazolam-ketamine as bolus for induction and midazolam-ketamine by continuous intravenous infusion for a 60 minute-period of maintenance. G2: the same as for G1. plus an increase in the midazolam dose during maintenance. G3: the same treatment as for G2, plus the addition of xylazine during maintenance. Immediately after induction the anesthetic maintenance started, and measures were taken 15 minutes after pre-medication, at 10 minutes intervals, during maintenance (M0 to M7).ResultsBradycardia, atrioventricular blockage, bradypnea and hypoxemia were shown in G3. G1 and G2 showed a slight hypotension only.ConclusionThere were some advantages by using the continuous intravenous via: no parameters oscillation and reduction in the anesthetic recovery period. The increase in midazolam dose brought about little parametric variations which were greater when xylazine was used, with a consequent hypoxemia, bradyarrhytmia, and decrease in respiratory frequency and minute volume.

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