• Bmc Neurol · Jan 2012

    Review Case Reports

    Recurrent aseptic meningitis in association with Kikuchi-Fujimoto disease: case report and literature review.

    • Tomoko Komagamine, Takahide Nagashima, Masaru Kojima, Norito Kokubun, Toshiki Nakamura, Kenich Hashimoto, Kazuhito Kimoto, and Koichi Hirata.
    • Department of Neurology, Dokkyo Medical University, Shimotsuga, Tochigi, Japan. tkoma@dokkyomed.ac.jp
    • Bmc Neurol. 2012 Jan 1; 12: 112.

    BackgroundKikuchi Fujimoto disease (KFD), or histiocytic necrotising lymphadenitis, is a benign and self-limiting condition characterised by primarily affecting the cervical lymph nodes. Recurrent aseptic meningitis in association with KFD is extremely rare and remains a diagnostic challenge.Case PresentationWe report a 28-year-old man who presented 7 episodes of aseptic meningitis associated with KFD over the course of 7 years. Histopathological findings of enlarged lymph nodes led to the diagnosis of KFD. The patient's headache and lymphadenopathy spontaneously resolved without any sequelae.ConclusionsA diagnosis of KFD should be considered when enlarged cervical lymph nodes are observed in patients with recurrent aseptic meningitis. A long-term prognosis remains uncertain, and careful follow-up is preferred.

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