• Fortschr Neurol Psychiatr · Aug 2009

    Review

    [Pathophysiology of neuronal injury in bacterial meningitis and experimental adjunctive therapeutic approaches].

    • T Böttcher.
    • Dietrich-Bonhoeffer-Klinikum, Klinik für Neurologie, S.-Allende-Strasse 30, Neubrandenburg. toboettcher@gmx.de
    • Fortschr Neurol Psychiatr. 2009 Aug 1; 77 Suppl 1: S7-9.

    AbstractIn bacterial meningitis, death and long-term neurological sequelae are caused jointly by several factors. Despite highly qualified intensive care and effective antibacterial therapy mortality rates remain high. Beta-lactam antibiotics, currently used for initial therapy of bacterial meningitis, lead to a rapid lysis of bacteria with a consecutive profound release of proinflammatory bacterial cell wall components, causing a substantial burst of meningeal inflammation. The only approved adjunctive therapy so far is corticosteroids. The use of nonbacteriolytic, protein-synthesis inhibiting antibiotics in experimental models of pneumococcal meningitis appeared to be a promising therapeutic approach towards neuroprotection by diminishing the inflammatory process.(c) Georg Thieme Verlag KG Stuttgart-New York.

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