Fortschritte der Neurologie-Psychiatrie
-
Multiple Sclerosis (MS) is associated with a chronic demyelinating and axonal injury to the central nervous system. Functional activation studies in MS patients have demonstrated that performance of simple motor tasks may activate non-canonical brain regions. ⋯ Rapid-onset neuronal plasticity in patients with mild-to-moderate MS is uncompromised despite many plasticity-impeding factors. Long-term adaptive mechanisms, relying on the formation on new neuronal connections, most likely are the principal mechanism underlying compensation of brain injury in MS.
-
Fortschr Neurol Psychiatr · Aug 2009
Review Historical Article[Disciplinary differentiation under socialist conditions--the establishment of neurology at the University of Rostock in East Germany].
The move towards disciplinary independence in Germany turned out to be more troublesome than in France or Great Britain and real institutional independence was not established at German universities until the 1970s of the 20th century, and this in the Federal Republic of Germany only. In East Germany (German Democratic Republic--GDR), a division into Chairs of Psychiatry and Neurology took place at individual universities and medical colleges only. ⋯ One such exception was the University of Rostock, where as early as 1958, the Chair of Psychiatry had been divided into three independent Chairs of Psychiatry, Neurology and Child Psychiatry. Besides internal scientific factors, socio-political constraints played a particular role here and had an influence on the disciplinary differentiation.
-
Fortschr Neurol Psychiatr · Aug 2009
Review[Pathophysiology of neuronal injury in bacterial meningitis and experimental adjunctive therapeutic approaches].
In bacterial meningitis, death and long-term neurological sequelae are caused jointly by several factors. Despite highly qualified intensive care and effective antibacterial therapy mortality rates remain high. ⋯ The only approved adjunctive therapy so far is corticosteroids. The use of nonbacteriolytic, protein-synthesis inhibiting antibiotics in experimental models of pneumococcal meningitis appeared to be a promising therapeutic approach towards neuroprotection by diminishing the inflammatory process.