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- J Classen, D Zeller, K aufm Kampe, and S Dang.
- Klinik und Poliklinik für Neurologie, Universität Leipzig A. ö. R., Liebigstrasse 20, Leipzig. Joseph.Classen@medizin.unileipzig.de
- Fortschr Neurol Psychiatr. 2009 Aug 1; 77 Suppl 1: S45-8.
AbstractMultiple Sclerosis (MS) is associated with a chronic demyelinating and axonal injury to the central nervous system. Functional activation studies in MS patients have demonstrated that performance of simple motor tasks may activate non-canonical brain regions. Using virtual lesion induction by transcranial magnetic stimulation, it is possible to show that this activation is functionally relevant. Rapid-onset neuronal plasticity in patients with mild-to-moderate MS is uncompromised despite many plasticity-impeding factors. Long-term adaptive mechanisms, relying on the formation on new neuronal connections, most likely are the principal mechanism underlying compensation of brain injury in MS.(c) Georg Thieme Verlag KG Stuttgart-New York.
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