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- Juan C Ramírez-Sandoval, Jonatan Barrera-Chimal, Perla E Simancas, Alejandro Rojas-Montaño, Ricardo Correa-Rotter, Norma A Bobadilla, and Luis E Morales-Buenrostro.
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Vasco de Quiroga 15, Mexico City , Mexico and.
- Biomarkers. 2014 Feb 1; 19 (1): 63-9.
ObjectiveEstablish the prognostic value for graft loss of urinary neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 (uKIM-1), interleukin-18 (uIL-18), and heat shock protein 72 (uHsp72) in kidney transplant recipients (KTR) with acute kidney injury (AKI).MethodsBiomarkers were measured in 67 KTR with AKI caused by different entities.ResultsAfter 1 year, 11 KTR with graft loss had higher uNGAL compared to KTR without loss (p < 0.001). There were no differences for uKIM-1, uIL-18 and uHsp-72. uNGAL >200 ng/mL had 84% sensitivity and 86% specificity for graft loss (ROC AUC: 0.89, 95% CI: 0.81-0.97). uNGAL may be useful to predict graft loss after AKI.
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