• Divyanshu Dubey, Anshudha Sawhney, Benjamin Greenberg, Andrea Lowden, Worthy Warnack, Pravin Khemani, Olaf Stuve, and Steven Vernino.
• Parkland Memorial Hospital, 5201 Harry Hines Blvd, Dallas, TX, USA; Department of Neurology & Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, USA.
• J. Neuroimmunol. 2015 Oct 15; 287: 93-7.

AbstractDespite being a potentially reversible neurological condition, no clear guidelines for diagnosis or management of autoimmune encephalitis exist. In this study we analyzed clinical presentation, laboratory and imaging characteristics, and outcome of autoimmune encephalitis from three teaching hospitals. Non-paraneoplastic autoimmune encephalitis associated with antibodies against membrane antigens was the most common syndrome, especially in the pediatric population. Clinical outcome was better for patients with shorter latency from symptom onset to diagnosis and initiation of immunomodulation. Patients with underlying malignancy were less likely to respond well to immunomodulatory therapy. The clinical spectrum of autoimmune encephalitis is fairly broad, but prompt recognition and treatment often leads to excellent outcome.Copyright © 2015 Elsevier B.V. All rights reserved.

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