• Am J Perinatol · Mar 2015

    Randomized Controlled Trial

    Effect of magnesium sulfate administration for neuroprotection on latency in women with preterm premature rupture of membranes.

    • Amanda L Horton, Yinglei Lai, Dwight J Rouse, Catherine Y Spong, Kenneth J Leveno, Michael W Varner, Brian M Mercer, Jay D Iams, Ronald J Wapner, Yoram Sorokin, John M Thorp, Susan M Ramin, Fergal D Malone, Mary J O'Sullivan, Gary D V Hankins, Steve N Caritis, and Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.
    • Department of Obstetrics and Gynecology, NorthShore University Health System, Evanston, Illinois.
    • Am J Perinatol. 2015 Mar 1; 32 (4): 387-92.

    ObjectiveThis study aims to evaluate whether magnesium sulfate administration for neuroprotection prolongs latency in women with preterm premature rupture of membranes (PPROM) between 24 and 31(6/7) weeks' gestation.Study DesignThis is a secondary analysis of a randomized controlled trial of magnesium sulfate for prevention of cerebral palsy. Gravid women with a singleton pregnancy between 24 and 31(6/7) weeks' gestation with PPROM without evidence of labor were randomized to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour up to 12 hours, or placebo. Maternal outcomes for this analysis were delivery in less than 48 hours and in less than 7 days from randomization. Neonatal outcomes included a composite of respiratory distress syndrome, interventricular hemorrhage grades 3 or 4, periventricular leukomalacia, sepsis, necrotizing enterocolitis, retinopathy of prematurity, or death.ResultsA total of 1,259 women were included. The rate of delivery < 48 hours was not different in the magnesium sulfate and the placebo groups (22.2 and 20.7%, p = 0.51). Delivery < 7 days was similar between groups (55.4 and 51.4%, p = 0.16). Median latency was also similar between groups (median [interquartile range], 6.0 days [range, 2.4-13.8 days] and 6.6 days [range, 2.4-15.1 days], p = 0.29). Composite neonatal outcomes did not differ between groups.ConclusionMagnesium sulfate administration given for neuroprotection in women with a singleton gestation with PPROM and without labor before 32 weeks does not impact latency.Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

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