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- James G Modir and Mark S Wallace.
- Department of Anesthesiology, University of California (UCSD), San Diego, CA, USA.
- Methods Mol. Biol. 2010 Jan 1; 617: 165-8.
AbstractThe cold pressor test is a reliable pain model in which subjects submerge their hands and forearms into ice water while onset to pain, pain intensity, and tolerance are assessed. Although originally developed as a model for hypertension, the paradigm leads to development of reproducible pain responses allowing assessment to analgesic medications. However, analgesic variability to various medications has been observed. A recent study suggests that methodological discrepancies may contribute to such inconsistencies. The model may be more reproducible by utilizing consistent protocols.
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