• Methods Mol. Biol. · Jan 2010

    Human experimental pain models 1: the ultraviolet light UV-B pain model.

    • James G Modir and Mark S Wallace.
    • Department of Anesthesiology, University of California (UCSD), La Jolla, CA, USA.
    • Methods Mol. Biol. 2010 Jan 1; 617: 159-64.

    AbstractThe UV-B pain model utilizes ultraviolet light to induce a small area of inflammation allowing assessment of mechanical and thermal thresholds. Pharmacologic testing has mainly focused on reduction of primary hyperalgesia, although the effect of analgesics on secondary hyperalgesia has also been investigated. The model requires an instrument to precisely generate controlled UV-B tissue hyperalgesia. Initially, a minimum dose to induce tissue hyperalgesia is determined; subsequently, dosages are delivered in set quantities. Tissue is then assessed for inflammation using color Doppler imaging or flare measurements. Heat pain thresholds and pain tolerance are often evaluated using a commercially available thermal sensory testing device. Analgesics can be administered to determine the influence on these clinical endpoints.

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